

| Каталожный номер | HC559014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human NR1D2 Polyclonal Antibody (HC559014) is a rabbit polyclonal antibody detecting NR1D2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human NR1D2 (Lys396-Pro579). | ||||||||
| Цель | Rev-erb alpha-related receptor, V-erbA-related protein 1-related, Rev-erb-beta, NR1D2, Orphan nuclear hormone receptor BD73, RVR, Nuclear receptor subfamily 1 group D member 2, EAR-1R | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q14995 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Nuclear receptor subfamily 1 group D member 2 (NR1D2) is a ~64 kDa protein. Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. | ||||||||
| Примечание | For research use only. |
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