Anti-Human NUDT3 Polyclonal Antibody (HF767014)

Name: Anti-Human NUDT3 Polyclonal Antibody
Brand: abinScience
SKU: HF767014
Price: 96 USD
Availability: InStock

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SDS

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Numéro de catalogue

HF767014

Description

Anti-Human NUDT3 Polyclonal Antibody (HF767014) is a rabbit polyclonal antibody detecting NUDT3 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human NUDT3 (Gly16-Ser163).

Cible

Diphosphoinositol polyphosphate phosphohydrolase 1, DIPP-1, 3.6.1.52, Diadenosine hexaphosphate hydrolase, Ap6A hydrolase, 3.6.1.61, Endopolyphosphatase, 3.6.1.10, Nucleoside diphosphate-linked moiety X motif 3, Nudix motif 3, m7GpppN-mRNA hydrolase, 3.6.1.62, m7GpppX diphosphatase, 3.6.1.59, NUDT3, DIPP, DIPP1

Purification

Purified by antigen affinity column.

Numéro d'accès

O95989

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Diphosphoinositol polyphosphate phosphohydrolase 1 (NUDT3) is a ~19 kDa protein. Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A.

1. Yang, X. et al. (1999) The Journal of biological chemistry 274, 35434-40. PMID: 10585413

2. Fisher, DI. et al. (2002) The Journal of biological chemistry 277, 47313-7. PMID: 12370170

3. Safrany, ST. et al. (1998) The EMBO journal 17, 6599-607. PMID: 9822604

4. Safrany, ST. et al. (1999) The Journal of biological chemistry 274, 21735-40. PMID: 10419486

5. Grudzien-Nogalska, E. et al. (2016) RNA (New York, N.Y.) 22, 773-81. PMID: 26932476

6. Sahu, S. et al. (2020) Proceedings of the National Academy of Sciences of the United States of America 117, 19245-19253. PMID: 32727897

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human NUDT3 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human NUDT3 Polyclonal Antibody (HF767014)

Aperçu

Images

Reférences

Fiche technique

SDS