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| カタログ番号 | HF767014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human NUDT3 Polyclonal Antibody (HF767014) is a rabbit polyclonal antibody detecting NUDT3 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NUDT3 (Gly16-Ser163). | ||||||||
| ターゲット | Diphosphoinositol polyphosphate phosphohydrolase 1, DIPP-1, 3.6.1.52, Diadenosine hexaphosphate hydrolase, Ap6A hydrolase, 3.6.1.61, Endopolyphosphatase, 3.6.1.10, Nucleoside diphosphate-linked moiety X motif 3, Nudix motif 3, m7GpppN-mRNA hydrolase, 3.6.1.62, m7GpppX diphosphatase, 3.6.1.59, NUDT3, DIPP, DIPP1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O95989 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Diphosphoinositol polyphosphate phosphohydrolase 1 (NUDT3) is a ~19 kDa protein. Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. 1. Yang, X. et al. (1999) The Journal of biological chemistry 274, 35434-40. PMID: 10585413 2. Fisher, DI. et al. (2002) The Journal of biological chemistry 277, 47313-7. PMID: 12370170 3. Safrany, ST. et al. (1998) The EMBO journal 17, 6599-607. PMID: 9822604 4. Safrany, ST. et al. (1999) The Journal of biological chemistry 274, 21735-40. PMID: 10419486 5. Grudzien-Nogalska, E. et al. (2016) RNA (New York, N.Y.) 22, 773-81. PMID: 26932476 6. Sahu, S. et al. (2020) Proceedings of the National Academy of Sciences of the United States of America 117, 19245-19253. PMID: 32727897 | ||||||||
| 注意事項 | For research use only. |
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