Anti-Human NUPR1 Polyclonal Antibody (HA758014)

Name: Anti-Human NUPR1 Polyclonal Antibody
Brand: abinScience
SKU: HA758014
Price: 168 USD
Availability: InStock

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Каталожный номер

HA758014

Описание

Anti-Human NUPR1 Polyclonal Antibody (HA758014) is a rabbit polyclonal antibody detecting Nuclear protein 1; Candidate of metastasis 1; Protein p8; NUPR1; COM1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant human NUPR1 (Ala2-Arg82).

Цель

Nuclear protein 1; Candidate of metastasis 1; Protein p8; NUPR1; COM1

Уровень эндотоксинов

Please contact with the lab for this information.

Очистка

Purified by antigen affinity column.

Номер доступа

O60356

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Nuclear protein 1 (NUPR1) is a ~8 kDa protein. Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in the regulation of many processes namely cell-cycle, apoptosis, autophagy and DNA repair responses. Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A. Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation. Negatively regulates apoptosis through interaction with PTMA.

1. Encinar, JA. et al. (2001) The Journal of biological chemistry 276, 2742-51. PMID: 11056169

2. Hoffmeister, A. et al. (2002) The Journal of biological chemistry 277, 22314-9. PMID: 11940591

3. Malicet, C. et al. (2006) Biochemical and biophysical research communications 339, 284-9. PMID: 16300740

4. Malicet, C. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 2671-6. PMID: 16478804

5. Clark, DW. et al. (2008) Current cancer drug targets 8, 421-30. PMID: 18690848

6. Gironella, M. et al. (2009) Journal of cellular physiology 221, 594-602. PMID: 19650074

7. Sambasivan, R. et al. (2009) Journal of cell science 122, 3481-91. PMID: 19723804

8. Kong, DK. et al. (2010) Molecular biology of the cell 21, 1335-49. PMID: 20181828

9. Hamidi, T. et al. (2012) The Journal of clinical investigation 122, 2092-103. PMID: 22565310

10. Vincent, AJ. et al. (2012) FEBS letters 586, 3429-34. PMID: 22858377

Примечание

For research use only

Изображения

Ссылки

Даташит

Anti-Human NUPR1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-Human NUPR1 Polyclonal Antibody (HA758014)

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