Anti-Human LOX-1/OLR1 Recombinant Antibody (SAA0778), APC (HX040137)

Name: Anti-Human LOX-1/OLR1 Recombinant Antibody (SAA0778), APC
Brand: abinScience
SKU: HX040137
Price: 290 USD
Availability: InStock

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概要
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概要

カタログ番号	HX040137
種反応性	Human
アプリケーション	FCM
宿主種	Mouse
クローン性	Monoclonal
アイソタイプ	IgG2a
クローンID	SAA0778
抱合	APC
ターゲット	C-type lectin domain family 8 member A, LOX-1, Ox-LDL receptor 1, Lectin-like oxidized LDL receptor 1, OLR1, Oxidized low-density lipoprotein receptor 1, Lectin-like oxLDL receptor 1, LOX1, CLEC8A, hLOX-1, Lectin-type oxidized LDL receptor 1
エンドトキシンレベル	Please contact with the lab for this information.
関連製品	Mouse IgG2a Recombinant Isotype Control Antibody (C1.18.4), APC
アクセッション番号	P78380
形態	Liquid
保存バッファー	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	Oxidized low-density lipoprotein receptor 1 (OLR1/LOX-1) is a ~30 kDa protein. Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation.
注意事項	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.