Anti-Human OPRM1 Polyclonal Antibody (HA561014)

Name: Anti-Human OPRM1 Polyclonal Antibody
Brand: abinScience
SKU: HA561014
Price: 168 USD
Availability: InStock

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Especificación:

50ug
100ug

Número:

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SDS

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Número de catálogo

HA561014

Descripción

Anti-Human OPRM1 Polyclonal Antibody (HA561014) is a rabbit polyclonal antibody detecting OPRM1. Suitable for Human.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human OPRM1 (Asp2-Ile68&Ala339-Pro400).

Objetivo

M-OR-1, MOP, MOR-1, MOR1, Mu opiate receptor, Mu opioid receptor, Mu-type opioid receptor, OPRM1, hMOP

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

P35372

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Fondo

Mu-type opioid receptor (OPRM1) is a ~44 kDa protein. Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15.

1. Zhang, P. et al. (1999) Brain research. Molecular brain research 72, 195-204. PMID: 10529478

2. Pan, YX. et al. (2003) Biochemical and biophysical research communications 301, 1057-61. PMID: 12589820

3. Mestek, A. et al. (1995) The Journal of neuroscience : the official journal of the Society for Neuroscience 15, 2396-406. PMID: 7891175

4. Wang, JB. et al. (1994) FEBS letters 338, 217-22. PMID: 7905839

5. Bare, LA. et al. (1994) FEBS letters 354, 213-6. PMID: 7957926

6. Bond, C. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 9608-13. PMID: 9689128

7. Law, PY. et al. (2000) Annual review of pharmacology and toxicology 40, 389-430. PMID: 10836142

8. Lopez, A. et al. (2009) Cellular and molecular life sciences : CMLS 66, 2093-108. PMID: 19300905

Nota

For research use only

Imágenes

Referencias

Datasheet

Anti-Human OPRM1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human OPRM1 Polyclonal Antibody (HA561014)

Vista general

Imágenes

Referencias

Datasheet

SDS