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| カタログ番号 | HP845014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human OSBPL2 (Ala96-Asp325). | ||||||||
| ターゲット | ORP-2, Oxysterol-binding protein-related protein 2, ORP2, OSBPL2, KIAA0772, OSBP-related protein 2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9H1P3 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Oxysterol-binding protein-related protein 2 (OSBPL2) is a ~55 kDa protein. Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane. Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate. Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro). 1. Wang, H. et al. (2019) Molecular cell 73, 458-473.e7. PMID: 30581148 2. Xu, Y. et al. (2001) The Journal of biological chemistry 276, 18407-14. PMID: 11279184 3. Suchanek, M. et al. (2007) The Biochemical journal 405, 473-80. PMID: 17428193 4. Hynynen, R. et al. (2009) Journal of lipid research 50, 1305-15. PMID: 19224871 | ||||||||
| 注意事項 | For research use only. |
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