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| カタログ番号 | HA252014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human OTUD1 Polyclonal Antibody (HA252014) is a rabbit polyclonal antibody detecting OTUD1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human OTUD1 (Met1-Ser481). | ||||||||
| ターゲット | DUBA7, DUBA-7, OTUD1, OTU domain-containing protein 1, OTDC1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q5VV17 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | OTU domain-containing protein 1 (OTUD1) is a ~51 kDa protein. Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin. Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination. The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598. OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation. 1. Mevissen, TE. et al. (2013) Cell 154, 169-84. PMID: 23827681 2. Snaurova, R. et al. (2022) Molecular and cellular biology 42, e0026522. PMID: 36445135 | ||||||||
| 注意事項 | For research use only. |
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