

| Numéro de catalogue | HP450014 | ||||||||
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| Description |
Anti-Human PANX1 Polyclonal Antibody (HP450014) is a rabbit polyclonal antibody detecting PANX1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human PANX1 (Ser236-Gln274). | ||||||||
| Cible | MRS1, Pannexin-1, PANX1 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q96RD7 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Pannexin-1 (PANX1) is a ~48 kDa protein. Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis. Forms anion-selective channels with relatively low conductance and an order of permeabilities: nitrate>iodide>chlroride>>aspartate=glutamate=gluconate. Can release ATP upon activation through phosphorylation or cleavage at C-terminus. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. 1. Bao, L. et al. (2004) FEBS letters 572, 65-8. PMID: 15304325 2. Vanden Abeele, F. et al. (2006) The Journal of cell biology 174, 535-46. PMID: 16908669 3. Bunse, S. et al. (2010) The Journal of biological chemistry 285, 38444-52. PMID: 20829356 4. Chekeni, FB. et al. (2010) Nature 467, 863-7. PMID: 20944749 5. Sang, Q. et al. (2019) Science translational medicine 11. PMID: 30918116 6. Medina, CB. et al. (2020) Nature 580, 130-135. PMID: 32238926 | ||||||||
| Note | For research use only. |
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