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| カタログ番号 | VK451023 | ||||||
|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human papillomavirus type 16 E6/Protein E6 Nanobody (SAA1338) [SAA1338] (VK451023) is a alpaca monoclonal antibody detecting Protein E6 in ELISA, IF, WB.
Highlights
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| 種反応性 | Human papillomavirus 16 (HPV16) | ||||||
| アプリケーション | ELISA, IF, WB | ||||||
| 宿主種 | Alpaca | ||||||
| クローン性 | Monoclonal | ||||||
| アイソタイプ | VHH-8His-Cys-tag | ||||||
| クローンID | SAA1338 | ||||||
| ターゲット | Protein E6, E6 | ||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||
| 精製 | Purified by Nickel column. | ||||||
| アクセッション番号 | P03126 | ||||||
| 形態 | Liquid | ||||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||
| 背景 | Protein E6 is a ~19 kDa protein. Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT). | ||||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human papillomavirus type 16 E6/Protein E6 Nanobody (SAA1338)
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