Anti-Human PCSK9 Recombinant Antibody (SAA0158), PE (HV275127)

Name: Anti-Human PCSK9 Recombinant Antibody (SAA0158), PE
Brand: abinScience
SKU: HV275127
Price: 290 USD
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Número de catálogo	HV275127
Reactividad de especies	Human
Aplicaciones	FCM
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG2, lambda
ID de clon	SAA0158
Conjugación	PE
Objetivo	EC:3.4.21.-, NARC-1, NARC1, Neural apoptosis-regulated convertase 1, PC9, PCSK9, Proprotein convertase 9, Proprotein convertase subtilisin/kexin type 9, Subtilisin/kexin-like protease PC9
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Productos asociados	Human IgG2 Recombinant Isotype Control Antibody (HyHEL-10), PE
Número de acceso	Q8NBP7
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 50% glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a ~74 kDa protein. Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. PCSK9 is the therapeutic target of evolocumab (Repatha). _x000D_ _x000D_ 1. Poirier, S. et al. (2008) The Journal of biological chemistry 283, 2363-72. PMID: 18039658 _x000D_ _x000D_ 2. Nassoury, N. et al. (2007) Traffic (Copenhagen, Denmark) 8, 718-32. PMID: 17461796 _x000D_ _x000D_ 3. Fan, D. et al. (2008) Biochemistry 47, 1631-9. PMID: 18197702 _x000D_ _x000D_ 4. Mayer, G. et al. (2008) The Journal of biological chemistry 283, 31791-801. PMID: 18799458 _x000D_ _x000D_ 5. Chen, Y. et al. (2011) Biochemical and biophysical research communications 415, 515-8. PMID: 22074827 _x000D_ _x000D_ 6. Jonas, MC. et al. (2008) EMBO reports 9, 916-22. PMID: 18660751
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.