Anti-Human Perforin Recombinant Antibody (SAA0104), APC (HB886137)

Name: Anti-Human Perforin Recombinant Antibody (SAA0104), APC
Brand: abinScience
SKU: HB886137
Price: 290 USD
Availability: InStock

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Número de catálogo	HB886137
Reactividad de especies	Human
Aplicaciones	FCM
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	SAA0104
Conjugación	APC
Objetivo	Cytolysin, Perforin-1, Lymphocyte pore-forming protein, PFP, PRF1, P1
Nivel de endotoxinas	Please contact with the lab for this information.
Productos asociados	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC
Número de acceso	P14222
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	Perforin-1 is a ~61 kDa protein. Pore-forming protein that plays a key role in granzyme-mediated programmed cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by mediating the passage and uptake of cytotoxic granzymes. 1. Praper, T. et al. (2011) The Journal of biological chemistry 286, 2946-55. PMID: 20889983 2. Law, RH. et al. (2010) Nature 468, 447-51. PMID: 21037563 3. Stewart, SE. et al. (2014) The Journal of biological chemistry 289, 9172-81. PMID: 24558045 4. Vergelli, M. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 158, 2756-61. PMID: 9058810 5. Ando, K. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 158, 5283-91. PMID: 9164947 6. Thiery, J. et al. (2010) Blood 115, 1582-93. PMID: 20038786 7. Czystowska, M. et al. (2010) Journal of molecular medicine (Berlin, Germany) 88, 577-88. PMID: 20225066 8. Zhou, Z. et al. (2020) Science (New York, N.Y.) 368. PMID: 32299851
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human Perforin Recombinant Antibody (SAA0104), APC.pdf

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