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| カタログ番号 | HF863014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human PEX14 Polyclonal Antibody (HF863014) is a rabbit polyclonal antibody detecting PEX14 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PEX14 (Arg25-Glu76). | ||||||||
| ターゲット | Peroxisomal membrane protein PEX14, PTS1 receptor-docking protein, Peroxin-14, PEX14, Peroxisomal membrane anchor protein PEX14 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O75381 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Peroxisomal membrane protein PEX14 is a ~41 kDa protein. Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin. 1. Neuhaus, A. et al. (2014) The Journal of biological chemistry 289, 437-48. PMID: 24235149 2. Dias, AF. et al. (2017) The Journal of biological chemistry 292, 15287-15300. PMID: 28765278 3. Fransen, M. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 8087-92. PMID: 9653144 4. Bharti, P. et al. (2011) Journal of cell science 124, 1759-68. PMID: 21525035 | ||||||||
| 注意事項 | For research use only. |
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