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| カタログ番号 | HP682013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, IF, IP | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a | ||||
| クローンID | SAA0216 | ||||
| ターゲット | [histone H3]-dimethyl-L-lysine(9) demethylase PHF8, KIAA1111, [histone H3]-dimethyl-L-lysine(36) demethylase PHF8, PHF8, ZNF422, Histone lysine demethylase PHF8, PHD finger protein 8 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q9UPP1 | ||||
| RRID | Anti-Human PHF8 IP Antibody (SAA0216) (abinScience Cat# HP682013, RRID:AB_3729750) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Histone lysine demethylase PHF8 is a ~117 kDa protein. Histone lysine demethylase with selectivity for mono- and dimethylated residues. It plays an essential role in cell cycle progression and rDNA transcription. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Displays a very low intrinsic activity toward dimethylated H3 'Lys-27' (H3K27Me2). 1. Loenarz, C. et al. (2010) Human molecular genetics 19, 217-22. PMID: 19843542 2. Zhu, Z. et al. (2010) Cell research 20, 794-801. PMID: 20531378 3. Qiu, J. et al. (2010) Cell research 20, 908-18. PMID: 20548336 4. Liu, W. et al. (2010) Nature 466, 508-12. PMID: 20622854 5. Yu, L. et al. (2010) Cell research 20, 166-73. PMID: 20101266 6. Feng, W. et al. (2010) Nature structural & molecular biology 17, 445-50. PMID: 20208542 7. Kleine-Kohlbrecher, D. et al. (2010) Molecular cell 38, 165-78. PMID: 20346720 8. Qi, HH. et al. (2010) Nature 466, 503-7. PMID: 20622853 9. Horton, JR. et al. (2010) Nature structural & molecular biology 17, 38-43. PMID: 20023638 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human PHF8 IP Antibody (SAA0216)
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