Anti-Human PIEZO1 Polyclonal Antibody (HP708014)

Name: Anti-Human PIEZO1 Polyclonal Antibody
Brand: abinScience
SKU: HP708014
Price: 168 USD
Availability: InStock

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50ug
100ug

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Datasheet
SDS

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Número de catálogo

HP708014

Descripción

Anti-Human PIEZO1 Polyclonal Antibody (HP708014) is a rabbit polyclonal antibody detecting PIEZO1 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human PIEZO1 (Gln2206-Lys2426).

Objetivo

Piezo-type mechanosensitive ion channel component 1, FAM38A, PIEZO1, Protein FAM38A, KIAA0233, Mib, Membrane protein induced by beta-amyloid treatment

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

Q92508, E2JF22, Q0KL00

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Reconstitución

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Envío

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Piezo-type mechanosensitive ion channel component 1 (PIEZO1) is a ~286 kDa protein. Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain. Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents.

1. Andolfo, I. et al. (2013) Blood 121, 3925-35, S1-12. PMID: 23479567

2. Albuisson, J. et al. (2013) Nature communications 4, 1884. PMID: 23695678

3. Gnanasambandam, R. et al. (2015) PloS one 10, e0125503. PMID: 25955826

4. Zhou, Z. et al. (2023) Science (New York, N.Y.) 381, 799-804. PMID: 37590348

5. McHugh, BJ. et al. (2010) Journal of cell science 123, 51-61. PMID: 20016066

6. Li, J. et al. (2014) Nature 515, 279-282. PMID: 25119035

7. Tsuchiya, M. et al. (2018) Nature communications 9, 2049. PMID: 29799007

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human PIEZO1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human PIEZO1 Polyclonal Antibody (HP708014)

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Imágenes

Referencias

Datasheet

SDS