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| カタログ番号 | HP708014 | ||||||
|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human PIEZO1 Polyclonal Antibody (HP708014) is a rabbit polyclonal antibody detecting PIEZO1 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||
| アプリケーション | ELISA, IHC, WB | ||||||
| 宿主種 | Rabbit | ||||||
| クローン性 | Polyclonal | ||||||
| アイソタイプ | IgG | ||||||
| 免疫原 | E. coli - derived recombinant Human PIEZO1 (Gln2206-Lys2426). | ||||||
| ターゲット | Piezo-type mechanosensitive ion channel component 1, FAM38A, PIEZO1, Protein FAM38A, KIAA0233, Mib, Membrane protein induced by beta-amyloid treatment | ||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||
| 精製 | Purified by antigen affinity column. | ||||||
| アクセッション番号 | Q92508, E2JF22, Q0KL00 | ||||||
| 形態 | Liquid | ||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. | ||||||
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. | ||||||
| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||
| 背景 | Piezo-type mechanosensitive ion channel component 1 (PIEZO1) is a ~286 kDa protein. Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain. Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents. 1. Andolfo, I. et al. (2013) Blood 121, 3925-35, S1-12. PMID: 23479567 2. Albuisson, J. et al. (2013) Nature communications 4, 1884. PMID: 23695678 3. Gnanasambandam, R. et al. (2015) PloS one 10, e0125503. PMID: 25955826 4. Zhou, Z. et al. (2023) Science (New York, N.Y.) 381, 799-804. PMID: 37590348 5. McHugh, BJ. et al. (2010) Journal of cell science 123, 51-61. PMID: 20016066 6. Li, J. et al. (2014) Nature 515, 279-282. PMID: 25119035 7. Tsuchiya, M. et al. (2018) Nature communications 9, 2049. PMID: 29799007 | ||||||
| 注意事項 | For research use only. |
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