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| カタログ番号 | HT068014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human PIK3CD Polyclonal Antibody (HT068014) is a rabbit polyclonal antibody detecting PIK3CD. Suitable for Mouse and Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PIK3CD (Val774-Gln1044). | ||||||||
| ターゲット | EC:2.7.1.137, EC:2.7.1.153, PI3-kinase subunit delta, PI3K-delta, PI3Kdelta, PIK3CD, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, PtdIns-3-kinase subunit delta, PtdIns-3-kinase subunit p110-delta, p110delta | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O00329 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD) is a ~119 kDa protein. Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. 1. Chantry, D. et al. (1997) The Journal of biological chemistry 272, 19236-41. PMID: 9235916 2. Meier, TI. et al. (2004) Protein expression and purification 35, 218-24. PMID: 15135396 | ||||||||
| 注意事項 | For research use only |
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