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| カタログ番号 | HP991014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PIKFYVE (Ala1864-Cys2098). | ||||||||
| ターゲット | Serine-protein kinase PIKFYVE, Phosphatidylinositol 3-phosphate 5-kinase, PIKfyve, 1-phosphatidylinositol 3-phosphate 5-kinase, PIKFYVE, FYVE finger-containing phosphoinositide kinase, Type III PIP kinase, PIPkin-III, KIAA0981, PIP5K3, Phosphatidylinositol 3-phosphate 5-kinase type III | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9Y2I7 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | 1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE) is a ~237 kDa protein. Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression. The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. 1. Shisheva, A. (2012) Current topics in microbiology and immunology 362, 127-62. PMID: 23086417 2. Sbrissa, D. et al. (2007) The Journal of biological chemistry 282, 23878-91. PMID: 17556371 3. Sbrissa, D. et al. (2012) American journal of physiology. Cell physiology 303, C436-46. PMID: 22621786 4. Lees, JA. et al. (2020) Molecular cell 80, 736-743.e4. PMID: 33098764 5. Baranov, MV. et al. (2019) iScience 11, 160-177. PMID: 30612035 6. Krishna, S. et al. (2016) Developmental cell 38, 536-47. PMID: 27623384 7. Dayam, RM. et al. (2017) Journal of immunology (Baltimore, Md. : 1950) 199, 2096-2105. PMID: 28779020 8. Liggins, MC. et al. (2018) PLoS genetics 14, e1007290. PMID: 29584722 9. Kim, J. et al. (2007) Cancer research 67, 9229-37. PMID: 17909029 | ||||||||
| 注意事項 | For research use only. |
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