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Anti-Human PIN1 Polyclonal Antibody (HC505014)

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Aperçu
Numéro de catalogueHC505014
Description
Anti-Human PIN1 Polyclonal Antibody (HC505014) is a rabbit polyclonal antibody detecting PIN1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman, Mouse
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human PIN1 (Glu51-Glu163).
Cible Rotamase Pin1, Peptidyl-prolyl cis-trans isomerase Pin1, PPIase Pin1, PIN1, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Purification Purified by antigen affinity column.
Numéro d'accès Q13526
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) is a ~18 kDa protein. Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes. Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK.

1. Lee, TH. et al. (2011) Molecular cell 42, 147-59. PMID: 21497122
2. Steger, M. et al. (2013) Molecular cell 50, 333-43. PMID: 23623683
3. Nechama, M. et al. (2018) Nature communications 9, 1603. PMID: 29686383
4. Lim, JH. et al. (2011) The Journal of biological chemistry 286, 44403-11. PMID: 22033920
5. Yu, L. et al. (2006) The Journal of biological chemistry 281, 18201-7. PMID: 16644721
6. Dougherty, MK. et al. (2005) Molecular cell 17, 215-24. PMID: 15664191
7. Phan, RT. et al. (2007) Nature immunology 8, 1132-9. PMID: 17828269
8. Min, SH. et al. (2012) Molecular cell 46, 771-83. PMID: 22608923
10. Li, X. et al. (2016) Molecular cell 61, 705-719. PMID: 26942675
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human PIN1 Polyclonal Antibody

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