中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HC505014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human PIN1 Polyclonal Antibody (HC505014) is a rabbit polyclonal antibody detecting PIN1 in ELISA, IHC, WB. Suitable for Human.
Highlights
|
||||||||
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PIN1 (Glu51-Glu163). | ||||||||
| ターゲット | Rotamase Pin1, Peptidyl-prolyl cis-trans isomerase Pin1, PPIase Pin1, PIN1, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13526 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) is a ~18 kDa protein. Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes. Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK. 1. Lee, TH. et al. (2011) Molecular cell 42, 147-59. PMID: 21497122 2. Steger, M. et al. (2013) Molecular cell 50, 333-43. PMID: 23623683 3. Nechama, M. et al. (2018) Nature communications 9, 1603. PMID: 29686383 4. Lim, JH. et al. (2011) The Journal of biological chemistry 286, 44403-11. PMID: 22033920 5. Yu, L. et al. (2006) The Journal of biological chemistry 281, 18201-7. PMID: 16644721 6. Dougherty, MK. et al. (2005) Molecular cell 17, 215-24. PMID: 15664191 7. Phan, RT. et al. (2007) Nature immunology 8, 1132-9. PMID: 17828269 8. Min, SH. et al. (2012) Molecular cell 46, 771-83. PMID: 22608923 10. Li, X. et al. (2016) Molecular cell 61, 705-719. PMID: 26942675 | ||||||||
| 注意事項 | For research use only. |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
