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| カタログ番号 | HP333014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PIP5K1A (Lys62-Lys452). | ||||||||
| ターゲット | PIP5K1-alpha, PtdIns(4)P-5-kinase 1 alpha, Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha, PIP5KIalpha, 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha, PIP5K1A, Phosphatidylinositol 4-phosphate 5-kinase type I alpha | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q99755 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A) is a ~62 kDa protein. Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility. PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis. Can also use phosphatidylinositol (PtdIns) as substrate in vitro. Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps. 1. Shulga, YV. et al. (2011) Journal of molecular biology 409, 101-12. PMID: 21477596 2. Shulga, YV. et al. (2012) The Journal of biological chemistry 287, 35953-63. PMID: 22942276 3. Loijens, JC. et al. (1996) The Journal of biological chemistry 271, 32937-43. PMID: 8955136 4. Xie, Z. et al. (2009) Molecular biology of the cell 20, 1695-704. PMID: 19158393 5. Chao, WT. et al. (2010) The Journal of cell biology 190, 247-62. PMID: 20660631 6. Mellman, DL. et al. (2008) Nature 451, 1013-7. PMID: 18288197 | ||||||||
| 注意事項 | For research use only. |
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