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Anti-Human Coagulation Factor II Monoclonal Antibody (1A302) (HF621025)

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Anti-Human Coagulation Factor II Monoclonal Antibody (1A302)
Anti-Human Coagulation Factor II Monoclonal Antibody (1A302)
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Vista general
Número de catálogoHF621025
Descripción
Anti-Human PIVKA-II/DCP Monoclonal Antibody (1A302) [1A302] (HF621025) is a mouse monoclonal antibody detecting Coagulation factor II in ELISA. Suitable for Human.
Reactividad de especiesHuman
AplicacionesELISA
Especie huéspedMouse
ClonalidadMonoclonal
IsotipoIgG
ID de clon1A302
Inmunógeno Human PIVKA-II/DCP Protein.
Objetivo Prothrombin, 3.4.21.5, Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain, F2
Nivel de endotoxinas Please contact with the lab for this information.
Pureza >95% as determined by SDS-PAGE.
Purificación Protein A/G purified from cell culture supernatant.
Número de acceso P00734
Forma Liquid
Buffer de almacenamiento 0.01M PBS pH 7.4.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Prothrombin (F2/PIVKA-II) is a ~70 kDa protein. Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces. Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells.

1. Naito, K. et al. (1991) The Journal of biological chemistry 266, 7353-8. PMID: 2019570
2. Choi, SH. et al. (2011) Blood 118, 6963-70. PMID: 21976677
3. Shinozawa, E. et al. (2018) Frontiers in pharmacology 9, 1431. PMID: 30568593
4. Senden, NH. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 161, 4318-24. PMID: 9780208
Nota For research use only.
Imágenes
  • Anti-Human Coagulation Factor II Monoclonal Antibody (1A302)

    SDS-PAGE

    SDS-PAGE for Anti-Human PIVKA-II/DCP Monoclonal Antibody (1A302)

Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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