Anti-Human PKD2 Polyclonal Antibody (HC405014)

Name: Anti-Human PKD2 Polyclonal Antibody
Brand: abinScience
SKU: HC405014
Price: 168 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HC405014

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human PKD2 (Met242-Thr468).

Objetivo

Autosomal dominant polycystic kidney disease type II protein, TRPP2, PC2, Polycystwin, Transient receptor potential cation channel subfamily P member 2, Polycystin-2, PKD2, Polycystic kidney disease 2 protein, R48321

Purificación

Purified by antigen affinity column.

Número de acceso

Q13563

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Polycystin-2 (PKD2) is a ~109 kDa protein. Forms a nonselective cation channel. Can function as a homotetrameric ion channel or can form heteromer with PKD1. Displays distinct function depending on its subcellular localization and regulation by its binding partners. In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium.

1. Koulen, P. et al. (2002) Nature cell biology 4, 191-7. PMID: 11854751

2. Gonzalez-Perrett, S. et al. (2002) The Journal of biological chemistry 277, 24959-66. PMID: 11991947

3. Köttgen, M. et al. (2005) The EMBO journal 24, 705-16. PMID: 15692563

4. Cantero, Mdel R. et al. (2015) The Journal of biological chemistry 290, 23888-96. PMID: 26269590

5. Arif Pavel, M. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, E2363-72. PMID: 27071085

6. Wang, Z. et al. (2019) EMBO reports 20, e48336. PMID: 31441214

7. Staudner, T. et al. (2024) The Journal of biological chemistry 300, 107574. PMID: 39009345

8. Ha, K. et al. (2020) eLife 9. PMID: 33164752

9. Kim, S. et al. (2016) Nature cell biology 18, 752-764. PMID: 27214281

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human PKD2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo