Anti-Human PKD2 Polyclonal Antibody (HC405014)

Name: Anti-Human PKD2 Polyclonal Antibody
Brand: abinScience
SKU: HC405014
Price: 168 USD
Availability: InStock

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50ug
100ug

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Aperçu
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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HC405014

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human PKD2 (Met242-Thr468).

Cible

Autosomal dominant polycystic kidney disease type II protein, TRPP2, PC2, Polycystwin, Transient receptor potential cation channel subfamily P member 2, Polycystin-2, PKD2, Polycystic kidney disease 2 protein, R48321

Purification

Purified by antigen affinity column.

Numéro d'accès

Q13563

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Polycystin-2 (PKD2) is a ~109 kDa protein. Forms a nonselective cation channel. Can function as a homotetrameric ion channel or can form heteromer with PKD1. Displays distinct function depending on its subcellular localization and regulation by its binding partners. In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium.

1. Koulen, P. et al. (2002) Nature cell biology 4, 191-7. PMID: 11854751

2. Gonzalez-Perrett, S. et al. (2002) The Journal of biological chemistry 277, 24959-66. PMID: 11991947

3. Köttgen, M. et al. (2005) The EMBO journal 24, 705-16. PMID: 15692563

4. Cantero, Mdel R. et al. (2015) The Journal of biological chemistry 290, 23888-96. PMID: 26269590

5. Arif Pavel, M. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, E2363-72. PMID: 27071085

6. Wang, Z. et al. (2019) EMBO reports 20, e48336. PMID: 31441214

7. Staudner, T. et al. (2024) The Journal of biological chemistry 300, 107574. PMID: 39009345

8. Ha, K. et al. (2020) eLife 9. PMID: 33164752

9. Kim, S. et al. (2016) Nature cell biology 18, 752-764. PMID: 27214281

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human PKD2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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