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| カタログ番号 | HC405014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PKD2 (Met242-Thr468). | ||||||||
| ターゲット | Autosomal dominant polycystic kidney disease type II protein, TRPP2, PC2, Polycystwin, Transient receptor potential cation channel subfamily P member 2, Polycystin-2, PKD2, Polycystic kidney disease 2 protein, R48321 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13563 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Polycystin-2 (PKD2) is a ~109 kDa protein. Forms a nonselective cation channel. Can function as a homotetrameric ion channel or can form heteromer with PKD1. Displays distinct function depending on its subcellular localization and regulation by its binding partners. In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. 1. Koulen, P. et al. (2002) Nature cell biology 4, 191-7. PMID: 11854751 2. Gonzalez-Perrett, S. et al. (2002) The Journal of biological chemistry 277, 24959-66. PMID: 11991947 3. Köttgen, M. et al. (2005) The EMBO journal 24, 705-16. PMID: 15692563 4. Cantero, Mdel R. et al. (2015) The Journal of biological chemistry 290, 23888-96. PMID: 26269590 5. Arif Pavel, M. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, E2363-72. PMID: 27071085 6. Wang, Z. et al. (2019) EMBO reports 20, e48336. PMID: 31441214 7. Staudner, T. et al. (2024) The Journal of biological chemistry 300, 107574. PMID: 39009345 8. Ha, K. et al. (2020) eLife 9. PMID: 33164752 9. Kim, S. et al. (2016) Nature cell biology 18, 752-764. PMID: 27214281 | ||||||||
| 注意事項 | For research use only. |
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