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| カタログ番号 | HA627014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human PLA2G5 Polyclonal Antibody (HA627014) is a rabbit polyclonal antibody detecting Phospholipase A2 group V; 3.1.1.4; PLA2-10; Phosphatidylcholine 2-acylhydrolase 5; PLA2G5 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human PLA2G5 (Gly21-Ser138). | ||||||||
| ターゲット | Phospholipase A2 group V; 3.1.1.4; PLA2-10; Phosphatidylcholine 2-acylhydrolase 5; PLA2G5 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P39877 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Phospholipase A2 group V (PLA2G5) is a ~15 kDa protein. Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), preferentially releasing fatty acyl groups with a low degree of unsaturation such as oleoyl (C18:1) and linoleoyl (C18:2) groups. Hydrolyzes low-density lipoprotein (LDL) phospholipids releasing unsaturated fatty acids that drive macrophage polarization toward an M2 phenotype. May act in an autocrine and paracrine manner. Contributes to lipid remodeling of cellular membranes at different subcellular locations and generation of lipid mediators involved in pathogen clearance. 1. Chen, J. et al. (1994) The Journal of biological chemistry 269, 2365-8. PMID: 8300559 2. Sun, YX. et al. (2004) The Biochemical journal 380, 749-56. PMID: 14998370 3. Hsu, YH. et al. (2013) PloS one 8, e59267. PMID: 23533611 4. Rubio, JM. et al. (2015) Journal of immunology (Baltimore, Md. : 1950) 194, 3327-39. PMID: 25725101 5. Koduri, RS. et al. (2002) The Journal of biological chemistry 277, 5849-57. PMID: 11694541 6. Kim, YJ. et al. (2002) The Journal of biological chemistry 277, 36479-88. PMID: 12124392 7. Muñoz, NM. et al. (2003) The Journal of biological chemistry 278, 38813-20. PMID: 12796497 | ||||||||
| 注意事項 | For research use only |
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