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| カタログ番号 | HA070014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human POFUT2 Polyclonal Antibody (HA070014) is a rabbit polyclonal antibody detecting POFUT2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human POFUT2 (Pro53-Tyr167). | ||||||||
| ターゲット | POFUT2, FUT13, Peptide-O-fucosyltransferase 2, GDP-fucose protein O-fucosyltransferase 2, KIAA0958, C21orf80, O-FucT-2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9Y2G5 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | GDP-fucose protein O-fucosyltransferase 2 (POFUT2) is a ~49 kDa protein. GDP-fucose protein O-fucosyltransferase involved in one of the two pathways responsible for protein O-linked fucosylation, a unique post-translational modification of cysteine-knotted proteins that regulates various biological functions. This pathway targets proteins with Thrombospondin type-1 (TSP1) repeats (TSR) in the endoplasmic reticulum. Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families (Probable). Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13. 1. Chen, CI. et al. (2012) The EMBO journal 31, 3183-97. PMID: 22588082 2. Wang, LW. et al. (2007) The Journal of biological chemistry 282, 17024-31. PMID: 17395588 3. Ricketts, LM. et al. (2007) The Journal of biological chemistry 282, 17014-23. PMID: 17395589 | ||||||||
| 注意事項 | For research use only. |
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