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| カタログ番号 | HY534014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human POLR3D Polyclonal Antibody (HY534014) is a rabbit polyclonal antibody detecting POLR3D in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human POLR3D (Val249-Arg398). | ||||||||
| ターゲット | DNA-directed RNA polymerase III subunit RPC4, RNA polymerase III subunit C4, DNA-directed RNA polymerase III subunit D, Protein BN51, RNA polymerase III 47 kDa subunit, RPC53 homolog, POLR3D, BN51, BN51T | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P05423 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | DNA-directed RNA polymerase III subunit RPC4 (POLR3D) is a ~44 kDa protein. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3E/RPC5 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation. 1. Hu, P. et al. (2002) Molecular and cellular biology 22, 8044-55. PMID: 12391170 2. Canella, D. et al. (2010) Genome research 20, 710-21. PMID: 20413673 3. Girbig, M. et al. (2021) Nature structural & molecular biology 28, 210-219. PMID: 33558764 4. Hou, H. et al. (2021) Nature communications 12, 6135. PMID: 34675218 5. Van Bortle, K. et al. (2022) Nature communications 13, 3007. PMID: 35637192 6. Ablasser, A. et al. (2009) Nature immunology 10, 1065-72. PMID: 19609254 7. Chiu, YH. et al. (2009) Cell 138, 576-91. PMID: 19631370 | ||||||||
| 注意事項 | For research use only. |
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