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| カタログ番号 | HB667014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human POU3F2 (Thr266-Gln351). | ||||||||
| ターゲット | Brain-specific homeobox/POU domain protein 2, POU domain, class 3, transcription factor 2, Brain-2, OTF7, Oct-7, Nervous system-specific octamer-binding transcription factor N-Oct-3, Brn-2, Octamer-binding protein 7, OCT7, Octamer-binding transcription factor 7, POU3F2, BRN2, OTF-7 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P20265 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | POU domain, class 3, transcription factor 2 (POU3F2) is a ~46 kDa protein. Transcription factor that plays a key role in neuronal differentiation. Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides. Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes. | ||||||||
| 注意事項 | For research use only. |
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