

| Каталожный номер | HC274014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human POU4F2 (Gly246-Lys336). | ||||||||
| Цель | POU domain, class 4, transcription factor 2, POU4F2, Brn-3B, BRN3B, Brain-3B, Brain-specific homeobox/POU domain protein 3B | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q12837 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | POU domain, class 4, transcription factor 2 (POU4F2) is a ~43 kDa protein. Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells. Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner. Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding. 1. Salichs, E. et al. (2009) PLoS genetics 5, e1000397. PMID: 19266028 2. Zhang, L. et al. (2013) Molecular vision 19, 1371-86. PMID: 23805044 | ||||||||
| Примечание | For research use only. |



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