Anti-Human PPARGC1A Polyclonal Antibody (HP446014)

Name: Anti-Human PPARGC1A Polyclonal Antibody
Brand: abinScience
SKU: HP446014
Price: 168 USD
Availability: InStock

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Обзор

Каталожный номер

HP446014

Описание

Anti-Human PPARGC1A Polyclonal Antibody (HP446014) is a rabbit polyclonal antibody detecting PPARGC1A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pig.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human PPARGC1A (Ser636-Arg798).

Цель

LEM6, PGC1A, PPARGC1, Ligand effect modulator 6, PGC-1-alpha, PPAR-gamma coactivator 1-alpha, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PPARGC-1-alpha, PPARGC1A, PGC1

Очистка

Purified by antigen affinity column.

Номер доступа

Q9UBK2

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) is a ~91 kDa protein. Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program.

1. Knutti, D. et al. (2000) Molecular and cellular biology 20, 2411-22. PMID: 10713165

2. Dominy, JE. et al. (2010) Biochimica et biophysica acta 1804, 1676-83. PMID: 20005308

3. Shin, JH. et al. (2011) Cell 144, 689-702. PMID: 21376232

4. Mays, SG. et al. (2017) Molecular pharmacology 92, 1-11. PMID: 28363985

5. Seacrist, CD. et al. (2020) Structure (London, England : 1993) 28, 830-846.e9. PMID: 32433991

8. Cho, Y. et al. (2013) The Journal of biological chemistry 288, 25207-25218. PMID: 23836911

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human PPARGC1A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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