Anti-Human PPM1D Polyclonal Antibody (HT072014)

Name: Anti-Human PPM1D Polyclonal Antibody
Brand: abinScience
SKU: HT072014
Price: 96 USD
Availability: InStock

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Обзор

Каталожный номер

HT072014

Описание

Anti-Human PPM1D Polyclonal Antibody (HT072014) is a rabbit polyclonal antibody detecting PPM1D in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human, Mouse

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human PPM1D (Ser96-Leu395).

Цель

Protein phosphatase 1D, 3.1.3.16, Protein phosphatase 2C isoform delta, PP2C-delta, Protein phosphatase magnesium-dependent 1 delta, p53-induced protein phosphatase 1, PPM1D, WIP1

Очистка

Purified by antigen affinity column.

Номер доступа

O15297

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Protein phosphatase 1D (PPM1D) is a ~66 kDa protein. Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity.

1. Ruark, E. et al. (2013) Nature 493, 406-10. PMID: 23242139

2. Lu, X. et al. (2005) Genes & development 19, 1162-74. PMID: 15870257

3. Fujimoto, H. et al. (2006) Cell death and differentiation 13, 1170-80. PMID: 16311512

4. An, H. et al. (2011) PloS one 6, e16427. PMID: 21283629

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human PPM1D Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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