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| カタログ番号 | HF783014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human PPP1R15A Polyclonal Antibody (HF783014) is a rabbit polyclonal antibody detecting PPP1R15A in ELISA, IHC, WB. Suitable for Human and Bovine.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PPP1R15A (Ala571-Asn621). | ||||||||
| ターゲット | GADD34, Protein phosphatase 1 regulatory subunit 15A, PPP1R15A, Growth arrest and DNA damage-inducible protein GADD34, Myeloid differentiation primary response protein MyD116 homolog | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O75807 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) is a ~73 kDa protein. Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing p53/TP53 phosphorylation on 'Ser-15'. Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux. Also acts a viral restriction factor by attenuating HIV-1 replication. 1. Choy, MS. et al. (2015) Cell reports 11, 1885-91. PMID: 26095357 2. Santos, CX. et al. (2016) The EMBO journal 35, 319-34. PMID: 26742780 3. Shi, W. et al. (2004) The Journal of cell biology 164, 291-300. PMID: 14718519 4. Yagi, A. et al. (2003) Journal of cellular biochemistry 90, 1242-9. PMID: 14635196 5. Gambardella, G. et al. (2020) Science advances 6. PMID: 32978159 6. Ishaq, M. et al. (2020) Virology 540, 119-131. PMID: 31778897 | ||||||||
| 注意事項 | For research use only. |
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