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| カタログ番号 | HX167014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human PPP2R2A Polyclonal Antibody (HX167014) is a rabbit polyclonal antibody detecting PPP2R2A in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PPP2R2A (Met1-Asn447). | ||||||||
| ターゲット | PP2A subunit B isoform R2-alpha, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, PP2A subunit B isoform PR55-alpha, PPP2R2A, PP2A subunit B isoform alpha, PP2A subunit B isoform B55-alpha | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P63151 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A) is a ~51 kDa protein. Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. 1. Mayer, RE. et al. (1991) Biochemistry 30, 3589-97. PMID: 1849734 2. Li, F. et al. (2020) Molecular cell 80, 410-422.e6. PMID: 33108758 | ||||||||
| 注意事項 | For research use only. |
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