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| カタログ番号 | HW456014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human PPP5C Polyclonal Antibody (HW456014) is a rabbit polyclonal antibody detecting PPP5C in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PPP5C (Asp22-Met499). | ||||||||
| ターゲット | PP-T, Protein phosphatase T, Serine/threonine-protein phosphatase 5, PPP5, PPT, PP5, PPP5C | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P53041 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Serine/threonine-protein phosphatase 5 (PPP5C) is a ~56 kDa protein. Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. 1. Wechsler, T. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 1247-52. PMID: 14734805 2. Ikeda, K. et al. (2004) Molecular endocrinology (Baltimore, Md.) 18, 1131-43. PMID: 14764652 3. Ali, A. et al. (2004) Genes & development 18, 249-54. PMID: 14871926 4. Zeke, T. et al. (2005) The Biochemical journal 385, 45-56. PMID: 15383005 5. Liu, F. et al. (2005) The Journal of biological chemistry 280, 1790-6. PMID: 15546861 6. Zhang, J. et al. (2005) Molecular and cellular biology 25, 9910-9. PMID: 16260606 7. Partch, CL. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 10467-10472. PMID: 16790549 8. von Kriegsheim, A. et al. (2006) Nature cell biology 8, 1011-6. PMID: 16892053 9. Kang, Y. et al. (2009) The Journal of biological chemistry 284, 9845-53. PMID: 19176521 10. Chatterjee, A. et al. (2010) The Journal of biological chemistry 285, 3872-3882. PMID: 19948726 | ||||||||
| 注意事項 | For research use only. |
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