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Anti-Human PPP6C Polyclonal Antibody (HT366014)

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Vista general
Número de catálogoHT366014
Descripción
Anti-Human PPP6C Polyclonal Antibody (HT366014) is a rabbit polyclonal antibody detecting PPP6C in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human PPP6C (Met1-Leu305).
Objetivo Serine/threonine-protein phosphatase 6 catalytic subunit, PP6C, 3.1.3.16, Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed, PPP6C, PPP6
Purificación Purified by antigen affinity column.
Número de acceso O00743
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Serine/threonine-protein phosphatase 6 catalytic subunit (PPP6C) is a ~35 kDa protein. Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7.

1. Kajino, T. et al. (2006) The Journal of biological chemistry 281, 39891-6. PMID: 17079228
2. Tan, P. et al. (2017) Molecular cell 68, 293-307.e5. PMID: 29053956
3. Li, M. et al. (2020) Protein & cell 11, 584-599. PMID: 32474700
4. Filali, M. et al. (1999) Journal of cellular biochemistry 73, 153-63. PMID: 10227379
5. Stefansson, B. et al. (2007) Cell cycle (Georgetown, Tex.) 6, 1386-92. PMID: 17568194
6. Kotak, S. et al. (2016) Journal of cell science 129, 3015-25. PMID: 27335426
7. Ni, G. et al. (2020) mBio 11. PMID: 32753499
Nota For research use only.
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Referencias
Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human PPP6C Polyclonal Antibody

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