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| カタログ番号 | HT366014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human PPP6C Polyclonal Antibody (HT366014) is a rabbit polyclonal antibody detecting PPP6C in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PPP6C (Met1-Leu305). | ||||||||
| ターゲット | Serine/threonine-protein phosphatase 6 catalytic subunit, PP6C, 3.1.3.16, Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed, PPP6C, PPP6 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O00743 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Serine/threonine-protein phosphatase 6 catalytic subunit (PPP6C) is a ~35 kDa protein. Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. 1. Kajino, T. et al. (2006) The Journal of biological chemistry 281, 39891-6. PMID: 17079228 2. Tan, P. et al. (2017) Molecular cell 68, 293-307.e5. PMID: 29053956 3. Li, M. et al. (2020) Protein & cell 11, 584-599. PMID: 32474700 4. Filali, M. et al. (1999) Journal of cellular biochemistry 73, 153-63. PMID: 10227379 5. Stefansson, B. et al. (2007) Cell cycle (Georgetown, Tex.) 6, 1386-92. PMID: 17568194 6. Kotak, S. et al. (2016) Journal of cell science 129, 3015-25. PMID: 27335426 7. Ni, G. et al. (2020) mBio 11. PMID: 32753499 | ||||||||
| 注意事項 | For research use only. |
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