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| カタログ番号 | HB890014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PRKACA (His40-Lys310). | ||||||||
| ターゲット | PRKACA, PKACA, PKA C-alpha, cAMP-dependent protein kinase catalytic subunit alpha | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P17612 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) is a ~40 kDa protein. Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, histone H1.4 (H1-4), PSMC5/RPT6, PJA2, RYR2, RORA, SOX9, UHRF1 and VASP. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. 1. Guan, H. et al. (2005) The Journal of biological chemistry 280, 9957-62. PMID: 15642694 2. D'Souza, T. et al. (2005) The Journal of biological chemistry 280, 26233-40. PMID: 15905176 3. Pasqualucci, L. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 395-400. PMID: 16387847 4. Xu, H. et al. (2008) Breast cancer research and treatment 107, 63-70. PMID: 17333334 5. Zhang, F. et al. (2007) The Journal of biological chemistry 282, 22460-71. PMID: 17565987 6. Xiao, B. et al. (2007) The Journal of biological chemistry 282, 30256-64. PMID: 17693412 7. Shirakawa, K. et al. (2008) Nature structural & molecular biology 15, 1184-91. PMID: 18836454 8. Wang, W. et al. (2010) Molecular and cellular biochemistry 338, 115-22. PMID: 19949837 9. Gambaryan, S. et al. (2010) The Journal of biological chemistry 285, 18352-63. PMID: 20356841 10. Murshid, A. et al. (2010) PloS one 5, e13830. PMID: 21085490 | ||||||||
| 注意事項 | For research use only. |
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