

| Numéro de catalogue | HF775014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human PRKRA Polyclonal Antibody (HF775014) is a rabbit polyclonal antibody detecting PRKRA in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| Reactivité des espèces | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human PRKRA (Asn126-Lys313). | ||||||||
| Cible | PKR-associated protein X, Protein activator of the interferon-induced protein kinase, PACT, PRKRA, RAX, PKR-associating protein X, Interferon-inducible double-stranded RNA-dependent protein kinase activator A, Protein kinase, interferon-inducible double-stranded RNA-dependent activator | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | O75569 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA) is a ~34 kDa protein. Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner. May function as regulator of gastric epithelial differentiation. | ||||||||
| Note | For research use only. |

Western blot analysis was performed using anti-PRKRA polyclonal antibody at 1μg/ml on various samples.
Lane 1: Rat testis lysate
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