Anti-Human PSEN1/Presenilin-1 Recombinant Antibody (SAA1782) (HW641013)

Name: Anti-Human PSEN1/Presenilin-1 Recombinant Antibody (SAA1782)
Brand: abinScience
SKU: HW641013
Price: 196 USD
Availability: InStock

Datasheet Compartir producto Copiar información

Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HW641013

Reactividad de especies

Human

Aplicaciones

ELISA

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG2a, kappa

ID de clon

SAA1782

Objetivo

PSEN1, AD3, Presenilin-1, Protein S182, PS-1, PSNL1, PS1-CTF12, PS1

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

P49768

RRID

Anti-Human PSEN1/Presenilin-1 Antibody (SAA1782) (abinScience Cat# HW641013, RRID:AB_3727544)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

Presenilin-1 (PSEN1) is a ~52 kDa protein. Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1.

1. Wolfe, MS. et al. (1999) Nature 398, 513-7. PMID: 10206644

2. Steiner, H. et al. (1999) Biochemistry 38, 14600-5. PMID: 10545183

3. Ray, WJ. et al. (1999) The Journal of biological chemistry 274, 36801-7. PMID: 10593990

4. Kulic, L. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 5913-8. PMID: 10811883

5. Berezovska, O. et al. (2000) Journal of neurochemistry 75, 583-93. PMID: 10899933

6. Edbauer, D. et al. (2003) Nature cell biology 5, 486-8. PMID: 12679784

7. Kimberly, WT. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 6382-7. PMID: 12740439

8. Fraering, PC. et al. (2004) Biochemistry 43, 9774-89. PMID: 15274632

9. Heilig, EA. et al. (2010) The Journal of biological chemistry 285, 22350-9. PMID: 20460383

10. Lu, P. et al. (2014) Nature 512, 166-170. PMID: 25043039

Nota

For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human PSEN1/Presenilin-1 Antibody (SAA1782)

Referencias

Datasheet

Anti-Human PSEN1/Presenilin-1 Recombinant Antibody (SAA1782).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo