Anti-Human PSEN1/Presenilin-1 Recombinant Antibody (SAA1782) (HW641013)

Name: Anti-Human PSEN1/Presenilin-1 Recombinant Antibody (SAA1782)
Brand: abinScience
SKU: HW641013
Price: 196 USD
Availability: InStock

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Spécification :

50ug
100ug
1mg

Nombre :

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Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HW641013

Reactivité des espèces

Human

Applications

ELISA

Espèce hôte

Mouse

Clonalité

Monoclonal

Isotype

IgG2a, kappa

ID de clone

SAA1782

Cible

PSEN1, AD3, Presenilin-1, Protein S182, PS-1, PSNL1, PS1-CTF12, PS1

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

P49768

RRID

Anti-Human PSEN1/Presenilin-1 Antibody (SAA1782) (abinScience Cat# HW641013, RRID:AB_3727544)

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

Presenilin-1 (PSEN1) is a ~52 kDa protein. Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1.

1. Wolfe, MS. et al. (1999) Nature 398, 513-7. PMID: 10206644

2. Steiner, H. et al. (1999) Biochemistry 38, 14600-5. PMID: 10545183

3. Ray, WJ. et al. (1999) The Journal of biological chemistry 274, 36801-7. PMID: 10593990

4. Kulic, L. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 5913-8. PMID: 10811883

5. Berezovska, O. et al. (2000) Journal of neurochemistry 75, 583-93. PMID: 10899933

6. Edbauer, D. et al. (2003) Nature cell biology 5, 486-8. PMID: 12679784

7. Kimberly, WT. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 6382-7. PMID: 12740439

8. Fraering, PC. et al. (2004) Biochemistry 43, 9774-89. PMID: 15274632

9. Heilig, EA. et al. (2010) The Journal of biological chemistry 285, 22350-9. PMID: 20460383

10. Lu, P. et al. (2014) Nature 512, 166-170. PMID: 25043039

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human PSEN1/Presenilin-1 Antibody (SAA1782)

Reférences

Fiche technique

Anti-Human PSEN1/Presenilin-1 Recombinant Antibody (SAA1782).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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