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| カタログ番号 | HW641013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1782 | ||||
| ターゲット | PSEN1, AD3, Presenilin-1, Protein S182, PS-1, PSNL1, PS1-CTF12, PS1 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P49768 | ||||
| RRID | Anti-Human PSEN1/Presenilin-1 Antibody (SAA1782) (abinScience Cat# HW641013, RRID:AB_3727544) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Presenilin-1 (PSEN1) is a ~52 kDa protein. Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1. 1. Wolfe, MS. et al. (1999) Nature 398, 513-7. PMID: 10206644 2. Steiner, H. et al. (1999) Biochemistry 38, 14600-5. PMID: 10545183 3. Ray, WJ. et al. (1999) The Journal of biological chemistry 274, 36801-7. PMID: 10593990 4. Kulic, L. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 5913-8. PMID: 10811883 5. Berezovska, O. et al. (2000) Journal of neurochemistry 75, 583-93. PMID: 10899933 6. Edbauer, D. et al. (2003) Nature cell biology 5, 486-8. PMID: 12679784 7. Kimberly, WT. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 6382-7. PMID: 12740439 8. Fraering, PC. et al. (2004) Biochemistry 43, 9774-89. PMID: 15274632 9. Heilig, EA. et al. (2010) The Journal of biological chemistry 285, 22350-9. PMID: 20460383 10. Lu, P. et al. (2014) Nature 512, 166-170. PMID: 25043039 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human PSEN1/Presenilin-1 Antibody (SAA1782)
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中国武漢市深敦寺路666号C棟、武漢、430206
