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| カタログ番号 | HT284014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PSMD14 (Gln30-Lys209). | ||||||||
| ターゲット | 26S proteasome non-ATPase regulatory subunit 14, 26S proteasome-associated PAD1 homolog 1, POH1, 26S proteasome regulatory subunit RPN11, PSMD14 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O00487 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ubiquitin C-terminal hydrolase PSMD14 is a ~34 kDa protein. Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. 1. Spataro, V. et al. (1997) The Journal of biological chemistry 272, 30470-5. PMID: 9374539 2. Kanayama, HO. et al. (1992) European journal of biochemistry 206, 567-78. PMID: 1317798 3. Butler, LR. et al. (2012) The EMBO journal 31, 3918-34. PMID: 22909820 4. Bustamante, HA. et al. (2020) Cells 9. PMID: 32210007 | ||||||||
| 注意事項 | For research use only. |
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