Anti-Human PTGES3/P23 Polyclonal Antibody (HS799014)

Name: Anti-Human PTGES3/P23 Polyclonal Antibody
Brand: abinScience
SKU: HS799014
Price: 96 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HS799014

Description

Anti-Human PTGES3/P23 Polyclonal Antibody (HS799014) is a rabbit polyclonal antibody detecting PTGES3/P23 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human PTGES3/P23 (Met1-Glu160).

Cible

PTGES3, Hsp90 co-chaperone, P23, Progesterone receptor complex p23, Prostaglandin E synthase 3, cPGES, Telomerase-binding protein p23, Cytosolic prostaglandin E2 synthase, TEBP

Purification

Purified by antigen affinity column.

Numéro d'accès

Q15185

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Prostaglandin E synthase 3 (PTGES3/P23) is a ~18 kDa protein. Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.

1. Tanioka, T. et al. (2000) The Journal of biological chemistry 275, 32775-82. PMID: 10922363

2. Forsythe, HL. et al. (2001) The Journal of biological chemistry 276, 15571-4. PMID: 11274138

3. Freeman, BC. et al. (2002) Science (New York, N.Y.) 296, 2232-5. PMID: 12077419

4. Song, D. et al. (2014) The Journal of biological chemistry 289, 14656-65. PMID: 24711448

Note

For research use only.

Images

Western blot

Lane 1: A549 cell lysate
Lane 2: PC-3 cell lysate
Lane 3: Hela cell lysate
Lane 4: HepG2 cell lysate
Lane 5: NIH3T3 cell lysate
Lane 6: 293T cell lysate
Lane 7: Mouse testis lysate
Lane 8: Mouse brain lysate
Lane 9: Mouse spleen lysate
Lane 10: Rat testis lysate
Lane11: Rat brain lysate

Reférences

Fiche technique

Anti-Human PTGES3/P23 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human PTGES3/P23 Polyclonal Antibody (HS799014)

Aperçu

Images

Reférences

Fiche technique

SDS