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| カタログ番号 | HS876014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PTPA (Gly101-Gly358). | ||||||||
| ターゲット | PP2A, subunit B', PR53 isoform, Serine/threonine-protein phosphatase 2A regulatory subunit 4, PPP2R4, PTPA, Serine/threonine-protein phosphatase 2A activator, Serine/threonine-protein phosphatase 2A regulatory subunit B', Phosphotyrosyl phosphatase activator | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q15257 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Serine/threonine-protein phosphatase 2A activator (PTPA) is a ~40 kDa protein. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A). Modulates PP2A activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). 1. Chao, Y. et al. (2006) Molecular cell 23, 535-46. PMID: 16916641 2. Fevga, C. et al. (2023) Brain : a journal of neurology 146, 1496-1510. PMID: 36073231 3. Azam, S. et al. (2007) Apoptosis : an international journal on programmed cell death 12, 1243-55. PMID: 17333320 | ||||||||
| 注意事項 | For research use only. |
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