Anti-Human PTPN22 Polyclonal Antibody (HB930014)

Name: Anti-Human PTPN22 Polyclonal Antibody
Brand: abinScience
SKU: HB930014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HB930014

Description

Anti-Human PTPN22 Polyclonal Antibody (HB930014) is a rabbit polyclonal antibody detecting PTPN22 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human PTPN22 (Met1-Gly303).

Cible

PTPN8, Lymphoid phosphatase, PTPN22, PEST-domain phosphatase, LyP, Tyrosine-protein phosphatase non-receptor type 22, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, PEP

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9Y2R2

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) is a ~91 kDa protein. Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2.

1. Wu, J. et al. (2006) The Journal of biological chemistry 281, 11002-10. PMID: 16461343

2. Yu, X. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 19767-72. PMID: 18056643

3. Yu, X. et al. (2011) The Journal of biological chemistry 286, 30526-30534. PMID: 21719704

4. Wang, Y. et al. (2013) Immunity 39, 111-22. PMID: 23871208

5. Spalinger, MR. et al. (2013) PloS one 8, e72384. PMID: 23991106

6. Spalinger, MR. et al. (2016) The Journal of clinical investigation 126, 1783-800. PMID: 27043286

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human PTPN22 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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