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| カタログ番号 | HA962014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human PTPRQ Polyclonal Antibody (HA962014) is a rabbit polyclonal antibody detecting PTPRQ in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PTPRQ (Arg1929-Met2299). | ||||||||
| ターゲット | Phosphatidylinositol phosphatase PTPRQ, R-PTP-Q, PTP-RQ, PTPRQ, Receptor-type tyrosine-protein phosphatase Q | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9UMZ3 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Phosphatidylinositol phosphatase PTPRQ is a ~260 kDa protein. Dephosphorylates phosphatidylinositol phosphates, such as phosphatidylinositol 3,4,5-trisphosphate (PIP3) and phosphatidylinositol 3,5-diphosphates, with preference for PIP3. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity in vitro; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by regulating the levels of PIP3 in MSCs and preadipocyte cells. 1. Yu, KR. et al. (2013) Acta crystallographica. Section D, Biological crystallography 69, 1522-9. PMID: 23897475 2. Jung, H. et al. (2009) Biochemical and biophysical research communications 383, 252-7. PMID: 19351528 3. Shahin, H. et al. (2010) Journal of medical genetics 47, 643-5. PMID: 20472657 4. Eisenberger, T. et al. (2018) Genetics in medicine : official journal of the American College of Medical Genetics 20, 614-621. PMID: 29309402 | ||||||||
| 注意事項 | For research use only. |
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