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Anti-Human PUM1 Polyclonal Antibody (HD611014)

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Aperçu
Numéro de catalogueHD611014
Description
Anti-Human PUM1 Polyclonal Antibody (HD611014) is a rabbit polyclonal antibody detecting PUM1. Suitable for Human and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human PUM1 (Ser830-Ile1186).
Cible HsPUM, KIAA0099, PUM1, PUMH1, Pumilio homolog 1, Pumilio-1
Niveau d'endotoxines Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Numéro d'accès Q14671
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Contexte

Pumilio homolog 1 (PUM1) is a ~126 kDa protein. Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle.

1. Gupta, YK. et al. (2008) Structure (London, England : 1993) 16, 549-57. PMID: 18328718
2. Lu, G. et al. (2011) Structure (London, England : 1993) 19, 361-7. PMID: 21397187
3. Filipovska, A. et al. (2011) Nature chemical biology 7, 425-7. PMID: 21572425
4. Dong, S. et al. (2011) The Journal of biological chemistry 286, 26732-42. PMID: 21653694
5. Van Etten, J. et al. (2012) The Journal of biological chemistry 287, 36370-83. PMID: 22955276
6. Galgano, A. et al. (2008) PloS one 3, e3164. PMID: 18776931
7. Kedde, M. et al. (2010) Nature cell biology 12, 1014-20. PMID: 20818387
8. Leibovich, L. et al. (2010) Silence 1, 17. PMID: 20860814
9. Miles, WO. et al. (2012) Genes & development 26, 356-68. PMID: 22345517
Note For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human PUM1 Polyclonal Antibody

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