Anti-Human Quaking/QKI Polyclonal Antibody (HP249014)

Name: Anti-Human Quaking/QKI Polyclonal Antibody
Brand: abinScience
SKU: HP249014
Price: 168 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HP249014

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human QKI (Thr14-Gly202).

Objetivo

QKI, HqkI, HKQ, Hqk, Protein quaking

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Purified by antigen affinity column.

Número de acceso

Q96PU8

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

KH domain-containing RNA-binding protein QKI is a ~37 kDa protein. RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation. Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons.

1. Fu, H. et al. (2012) Molecular biology of the cell 23, 1628-35. PMID: 22398723

2. Teplova, M. et al. (2013) Genes & development 27, 928-40. PMID: 23630077

3. Conn, SJ. et al. (2015) Cell 160, 1125-34. PMID: 25768908

4. de Bruin, RG. et al. (2016) Nature communications 7, 10846. PMID: 27029405

5. Caines, R. et al. (2019) Journal of cell science 132. PMID: 31331967

6. Zhao, Z. et al. (2023) Cell 186, 3208-3226.e27. PMID: 37379838

7. Liao, KC. et al. (2020) RNA biology 17, 366-380. PMID: 31829086

8. Liao, KC. et al. (2021) Nucleic acids research 49, 10034-10045. PMID: 34428287

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human Quaking/QKI Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo