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| カタログ番号 | HP249014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human QKI (Thr14-Gly202). | ||||||||
| ターゲット | QKI, HqkI, HKQ, Hqk, Protein quaking | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q96PU8 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | KH domain-containing RNA-binding protein QKI is a ~37 kDa protein. RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation. Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons. 1. Fu, H. et al. (2012) Molecular biology of the cell 23, 1628-35. PMID: 22398723 2. Teplova, M. et al. (2013) Genes & development 27, 928-40. PMID: 23630077 3. Conn, SJ. et al. (2015) Cell 160, 1125-34. PMID: 25768908 4. de Bruin, RG. et al. (2016) Nature communications 7, 10846. PMID: 27029405 5. Caines, R. et al. (2019) Journal of cell science 132. PMID: 31331967 6. Zhao, Z. et al. (2023) Cell 186, 3208-3226.e27. PMID: 37379838 7. Liao, KC. et al. (2020) RNA biology 17, 366-380. PMID: 31829086 8. Liao, KC. et al. (2021) Nucleic acids research 49, 10034-10045. PMID: 34428287 | ||||||||
| 注意事項 | For research use only. |
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